17 Dec 2010 Endometrial cancer is a common malignancy, and its incidence is growing with an ageing population, increasing obesity and a general decline in fertility. 2006;101:120-5. Significant heterogeneity was found for sensitivity (I2 = 74.48%; Cochran Q = 27.43; p<0.001) and specificity (I2 = 93.45%; Cochran Q = 106.89; p<0.001). Obstet Gynecol Clin North Am. Department of Obstetrics and Gynecology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain Diagnostic strategies for endometrial cancer in women with postmenopausal bleeding: cost-effectiveness of individualized strategies. BMI is used to determine whether a person is underweight, normal weight, overweight, or obese. Endometrial volume and vascularity measurements by transvaginal 3-dimensional ultrasonography and power Doppler angiography in stimulated and tumoral endometria: an interobserver reproducibility study. Endometrial cancer usually is treated with surgery. 2012;119:14-7. Long B et al. Higgins JP et al. Risk of endometrial cancer and endometrial hyperplasia with atypia in asymptomatic postmenopausal women with endometrial thickness ≥11 mm: a systematic review and meta-analysis. Ann Intern Med. Breijer MC et al. It occurs most often in postmenopausal women. The purpose of these visits is to make sure that you stay healthy. Keeping your ovaries means that you may be able to use your own eggs for in vitro fertilization (IVF). 2002;19:69-75. J Ultrasound Med. J Clin Ultrasound. Bivariate modelling showed that a threshold effect explained this heterogeneity with three studies involved.16,17,19. Gupta JK et al.
Erdem B et al. Why Annual Pap Smears Are History – But Routine Ob-Gyn Visits Are Not, Copyright 2020 American College of Obstetricians and Gynecologists, Privacy Statement Ultrasound Obstet Gynecol. A rough comparison with the results from a recent meta-analysis focussed on endometrial thickness suggests that endometrial volume appears inferior to endometrial thickness.2 However, a formal meta-analytical comparison has not been performed so far.
Read common questions on the coronavirus and ACOG’s evidence-based answers. In women with postmenopausal bleeding, the most recent meta-analysis has demonstrated that an endometrial thickness <5 mm is effective to rule out endometrial cancer, with a high sensitivity (96.2%) and negative predictive value (99.3%), but rather low specificity (51.5%).2. Stage IV is the most advanced. Anesthesia is given to make you more comfortable. J Clin Epidemiol. Concerning applicability, for the patient selection domain, index test, and referent test, all studies were considered low risk for applicability because they used an adequate technique (transvaginal ultrasound) in the adequate clinical setting (postmenopausal bleeding) with an adequate reference standard (endometrial biopsy). The lining of the uterus may thicken in certain places. All inclusion and exclusion criteria for studies to be selected were defined, as well as how data extraction and quality assessment had to be performed before starting the data search. Diagnosis and treatment of EIN can prevent it from becoming cancer. Stages of cancer range from I to IV. 2005;1:1-14. Cho HJ et al. Ultrasound Obstet Gynecol. Endometrial carcinoma typically presents in the post-menopausal years with an average of age of 59 years old. European Medical Journal is for informational purposes and should not be considered medical advice, diagnosis or treatment recommendations. Read copyright and permissions information. *Correspondence to [email protected]. 2012;40:621-9. For the reference test domain, whether the study reported on the reference standard used (histology or not) and how sample was obtained was considered.
6. Trans-vaginal ultrasound (TVS) is a technique that is used to measure the thickness of the endometrium, which correlates with cancer development. Quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool. Privacy Policy 5. The test would be more cost-effective if it were restricted to women identified as being at high risk.
2015;136:E359-86. Yaman C et al. Gynecol Oncol. It should be borne in mind that 25–34% of the Type II endometrial cancer could be present in patients with thin or indistinct endometrium.42-43 The authors have no information about endometrial volume in these cases. Lymph Nodes: Small groups of special tissue that carry lymph, a liquid that bathes body cells. Smith-Bindman R et al.
Jacobs, I., Gentry-Maharaj, A, Burnell, M. and 29 others (2010) Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort The Lancet Oncology, published online ahead of print 13 December 2010 doi:10.1016/S1470-2045(10)70268-0, 2. Methods: An extensive search of papers analysing the role of endometrial volume calculated by 3D ultrasound for diagnosing endometrial carcinoma in women with postmenopausal bleeding was performed in MEDLINE/PubMed and Web of Science from January 1996 to January 2020. Information on the diagnostic performance of endometrial volume was extracted. This meta-analysis has been performed according to the PRISMA statement and the Synthesizing Evidence from Diagnostic Accuracy Tests (SEDATE) guidelines.11 The protocol was not registered, a decision made by the researchers to avoid delays in starting the meta-analysis.
Endometrial intraepithelial neoplasia (EIN) is a condition that may lead to type 1 endometrial cancer. 1.
Kim A et al. 2014;18:55-70. Screening tests are available, but these are currently recommended only for … After exclusion of 120 duplicate records, 198 citations remained.
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